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[] Download SD Files (.sdf) Contact Us Order Compounds Online The Company Brief Profile Why Life Chemicals Life Chemicals Team Facilities Events and Conferences Collaboration Opportunities Promotional materials R&D Highlights Careers FAQ Contacts Screening Libraries HTS Compound Collection Targeted and Focused Screening Libraries Covalent Inhibitor Libraries Fsp 3 -enriched Library 3D Compound Libraries for HTS Natural Product-like Compound Library Biologically Active Compound Library Al-generated Screening Compound Sets Phenotypic Screening Libraries Lead-like Screening Compound Library Scaffolds and Scaffold-based Compounds Tangible Screening Compounds Pre-plated Sets Pre-plated Diversity Sets Pre-plated Focused Libraries Pre-plated Fragment Screening Sets Fragment Libraries Building Blocks Contract Research Early Drug Discovery Custom Synthesis Computational Chemistry Analogue Search Library Synthesis Fine Chemicals by SynbiaS In Vitro ADMET Order and Supply Three Easy Steps Quality Control Formatting Options Terms and Conditions How to work with SD files Downloads Screening Libraries Fragment Libraries Building Blocks Custom Synthesis Our hearts stay with all invincible Ukrainians fighting for their freedom! You can be proud of your support and donation for Ukraine’s medical and humanitarian needs! CLICK TO DONATE! Stop business with Russia! Do not be involved with the aggressor! Featured Products Read More Pre-plated Diversity Sets new We present the latest collection of over 100,000 drug-like screening compounds, selected through a dissimilarity search based on our newly synthesized small molecules. They possess optimal physicochemical properties suitable for drug discovery and hit finding in broad-spectrum HTS campaigns, including multi-target or new-target phenotypic screening. Additionally, we offer complementary Diversity Subsets consisting of 5k, 10k, 15k, and 20k drug-like compounds with no structural overlap. Read More Autophagy Screening Compound Library new Targeting autophagic pathways is a promising strategy in drug discovery for treating cancer, neurodegenerative diseases, infections, and cardiac ischemia. With this in mind, we are offering over 6,200 autophagy-associated screening compounds, including predicted mTOR and PI3K inhibitors, apoptosis regulators, ROS and AMPK modulators, and other relevant protease and kinase inhibitors. Read More Mectin-based Screening Library new Our scientific team provides the world's most extensive collection of synthetic mectin derivatives, with over 250 compounds available in stock. As known, naturally occurring and biotechnologically derived mectins are highly effective insecticides, acaricides, and antiviral agents, hydrolytically convertible into monoglycosides and aglycones. These compounds have proven to treat various diseases, including cancer, and are essential in antiparasitic, antibacterial, antifungal, antiviral, and anti-COVID drugs. Read More Peptidomimetic Compound Library updated Peptidomimetics are small organic molecules that mimic pharmacophores of natural peptides or proteins in 3D space. We present a dedicated Screening Set comprising over 6,600 α-helix and β-turn mimetics, selected from our proprietary HTS Compound Collection using a ligand-based approach. This Library was created using various similarity analysis techniques, including structural similarity search against known peptidomimetic inhibitors and scaffolds, 3D shape screening, pharmacophore screening, and complex substructure search. Read More Covalent Screening Library updated As of today, available is our proprietary collection of 50,000 potential covalent binders to support covalent screening projects in drug discovery. These small-molecule compounds contain covalent warheads that form bonds with amino acid residues in target protein binding sites. Additional focused sets targeting specific amino acid residues can be provided on your request. Read More RNA Screening Libraries updated We are pleased to introduce our latest collection of RNA Screening Libraries, featuring over 29,000 small-molecule compounds with predicted RNA-binding activity. Utilizing various cheminformatics methods, such as 2D Similarity Search, Bayesian Modeling, and Exact Match, this collection is ideal for research on post-transcriptional gene regulation and antibacterial and antiviral drug discovery. Noteworthy, a subset focused on Human RNA is also available. Read More Chemoinformatic Clustered Compound Library new Using the Bemis-Murcko scaffolding approach, this collection features unique and diverse core structures, enabling the exploration of chemical space with exceptional diversity and specificity. By decomposing complex molecules into their fundamental scaffolds, we have curated a screening set comprising over 75,000 compounds. It serves as a foundational tool for structure-based drug design (SBDD), enabling the systematic evaluation of scaffold-activity relationships. Read More Celiac Disease Screening Library new Celiac Disease (CD) is an inheritable autoimmune disease characterized by a severe immune response to gluten protein. The inhibition of proteins that partake in the proinflammatory immune reaction cascade or regulate the tight junction is considered one of the most feasible strategies for combating the disease. We offer 1,200 drug-like screening compounds that are predicted to target protein-glutamine gamma-glutamyltransferase 2 (TG2), responsible for the enzymatic modification of gliadin peptides, a key mechanism in the pathogenesis of celiac disease. Read More Antiviral Screening Libraries new Our Antiviral Libraries designed using 2D Similarity or a combination of ligand- and structure-based approaches are sure to give a significant impetus to high-throughput screening (HTS) and high-content screening (HCS) projects. Over 20,000 drug-like screening compounds with potential antiviral activity against various virus species and antiviral molecular targets were selected. Additionally, 1,300 structurally diverse molecules were identified by structural virtual screening against targets relevant to antiviral therapy. Subscribe to our newsletter: Latest News Read More October 15, 2024 Complete Update of Fragment Libraries for FBDD Explore our updated Fragment Libraries of nearly 65,000 fragments. Get immediate access to diverse, customizable, assay-ready sets for your FBDD needs. Read More September 26, 2024 Life Chemicals and Variational AI Collaborate to Create AI-Designed Compound Libraries By targeting critical kinases and GPCRs with the help of AI-driven de novo compound generation, this bilateral collaboration will provide remarkably efficient tools for your drug discovery projects. Read More September 23, 2024 New Publication: Spirocyclic Hybrids of Nortropane and 1,3-Oxazinan-2-one Fragments A new publication by our scientific team to contribute to avant-garde organic synthesis and medicinal chemistry. News Archive Life Chemicals to participate in: FBLD 2024 September 22-24 Boston MA, USA Drug Discovery Chemistry Europe December 3-5 Barcelona, Spain All Events Latest Blog Posts Read More 10 september 2024, 15:08 Targeting RNA vs proteins in drug discovery Read More 13 july 2024, 20:06 Chirality Perspective in Drug Design and Development Read More 03 june 2024, 13:27 Navigating Autophagy: A Path to Drug Discovery All Posts Copyright © 2023 Life Chemicals All rights reserved. Privacy & Terms Novel small molecules, custom chemistry, early drug discovery services Contact Life Chemicals Worldwide orders@lifechemicals.com +1 800 591 9710 This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. By using our website, you accept our conditions of use of cookies to track data and create content (including advertising) based on your interest. Accept We are proud of Ukraine’s resilience! Dear Customer, Life Chemicals has fully resumed its production and services at its Kyiv site, supporting its customers’ HTS and building blocks programs and contributing to the restoration of the country’s economy! Always new and best chemistry – yours to explore! You can place orders and inquiries for the whole stock of our Screening Compounds and Building Blocks . Contact us at orders@lifechemicals.com for more information and quotations. The Life Chemicals Team is confident of the Company’s strong potential to quickly and successfully restart and grow, keeping pace with the highest market demands! STAND WITH UKRAINE: CLICK TO DONATE! For your convenience, we have also prepared a list of our selected products that are readily available for swift delivery worldwide directly from our USA- and Germany-based facilities: Pre-plated Diversity Sets , Pre-plated Focused Libraries , Pre-plated Fragment Screening Sets , Building Blocks (USA & EU Stock) . Please note that Ukranian courier services are not completely operational due to Russia’s invasion of Ukraine, and the delivery time for the main stock may take longer than usual. Thank you for your understanding and support! Yours sincerely, Life Chemicals team Close