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[] Download SD Files (.sdf) Contact Us Order Compounds Online The Company Brief Profile Why Life Chemicals Life Chemicals Team Facilities Events and Conferences Collaboration Opportunities Promotional materials R&D Highlights Careers FAQ Contacts Screening Libraries HTS Compound Collection Targeted and Focused Screening Libraries Fsp 3 -enriched Library 3D Compound Libraries for HTS Natural Product-like Compound Library Biologically Active Compound Library Phenotypic Screening Libraries Covalent Inhibitor Libraries Scaffolds and Scaffold-based Compounds Tangible Screening Compounds Pre-plated Sets Pre-plated Diversity Sets Pre-plated Focused Libraries Pre-plated Fragment Screening Sets Fragment Libraries Building Blocks Contract Research Early Drug Discovery Custom Synthesis Computational Chemistry Analogue Search Library Synthesis In Vitro ADMET Order and Supply Three Easy Steps Quality Control Formatting Options Terms and Conditions How to work with SD files Downloads Screening Libraries Fragment Libraries Building Blocks Custom Synthesis On February 24, 2022, the life of the Ukrainian people changed forever! Russia invaded the territory of Ukraine and the war started in the center of Europe! Now the bell tolls for everyone! Russia’s unprecedented and atrocious invasion is destroying not only the country’s economy but bringing inhuman suffering to the civilians. Stop business with Russia! Do not be involved with the aggressor! Our heart stays with all Ukrainians currently fighting for their freedom. Your donation for medical and humanitarian needs will help tremendously! CLICK TO DONATE! Featured Products Read More Pre-plated Focused Libraries: Latest additions new Our collection of screening libraries in pre-plated format is growing rapidly! Take advantage of the most favorable terms to boost your hit-finding HTS drug discovery projects! Recently we’ve added a kinase diversity set, 3D-shaped molecules, antibacterial compounds as well as PPI and PI3K/Akt/mTOR inhibitors in pre-plated assay-ready format. All compounds are synthesized in-house and several formatting options are available. Read More Pre-plated Diversity Sets new Our exclusive non-overlapping Pre-plated Diversity Sets containing 50,000 novel structurally diverse molecules were selected by dissimilarity search to provide a higher variety and broader chemical space coverage. They are an ideal starting kit for phenotypic and target-based HTS. Smaller subsets of 5,000, 10,000, 15,000, and 20,000 screening compounds are also available to meet your research needs. Read More Diversity Fragment Subsets updated We have applied our broad expertise in medicinal chemistry to provide you with compact screening sets, a perfect starting point for FBDD campaigns. They contain 960 or 1600 of our best fragment-like molecules with maximal structure diversity to cover the broadest chemical space. Specific subsets are available to provide the most suitable solutions to different research approaches: fluorinated and brominated compounds, Fsp³-enriched molecules, and potential covalent binders. Read More Advanced Building Block Collection updated Our proprietary collection of building blocks is predominantly based on rare chemotypes with favorable physicochemical parameters. The Life Chemicals R & D team performs the design and in-house synthesis of novel molecules, chemical intermediates, and fine reagents bearing various reactive functional groups to provide the most promising reagents for medicinal chemistry and drug design. Read More Natural Product-like Compound Libraries updated We have selected over 7,700 synthetic compounds similar to natural ones applying cheminformatics approaches (chemical descriptor calculation and natural-likeness scoring) and similarity to natural compound scaffolds. This is a perfect tool for high throughput screening (HTS) and high content screening (HCS) programs in modern drug discovery. Read More Covalent Screening Library updated A proprietary collection of 34,700 potential covalent modifiers was prepared to best suit various covalent screening projects in drug discovery. These small-molecule screening compounds contain covalent warheads known to form covalent bonds with amino acid residues in binding sites of target proteins. Additional focused sets of covalent binders targeting specific amino acid residues can be provided on request. Read More 3D Compound Libraries for HTS new The 3D shape of a free ligand is a crucial feature for its molecular recognition by the desired biomolecule and affinity to the binding site. Explore our new proprietary collection of over 30,000 non-planar sp3-rich screening compounds with diverse and well-developed 3D shapes as remarkably attractive molecules for HTS in modern drug discovery. Read More Serine Protease Screening Libraries new Our freshly picked Serine Protease Targeted Library contains 6,400 structurally-diverse screening compounds picked out by receptor-based virtual molecular screening with predicted inhibitory activity against main serine proteases: trypsin, chymotrypsin, a subtilisin-like serine protease, thrombin, factor Xa (FXA), and elastase. Serine proteases are involved in digestion coordination, inflammation, blood clotting, and immune system performance and represent a promising drug target family. Subscribe to our newsletter: Latest News Read More April 20, 2022 Proud of Ukraine’s resilience! Life Chemicals has fully resumed its production and services at its Kyiv site. Please place your orders and inquiries for the whole stock of our Screening Compounds and Building Blocks. Read More April 13, 2022 Life Chemicals to Participate in 2022 Drug Discovery Chemistry We are happy to be able to eventually meet our customers in person in San Diego, USA on April 18-21, 2022 to present an update on our latest screening libraries and drug discovery CRO services. Read More April 04, 2022 Find Answers to All Your Questions in Our FAQ Update We’ve put together some commonly asked questions to give user-oriented current information about our products and services. News Archive Life Chemicals to participate in: Drug Discovery Chemistry April 18-21, 2022 San Diego, CA, USA 3rd MMC - Molecules Medicinal Chemistry Symposium July 27-29, 2022 Rome, Italy All Events Copyright © 2021 Life Chemicals All rights reserved. Privacy & Terms Novel small molecules, custom chemistry, early drug discovery services Contact Life Chemicals Worldwide orders@lifechemicals.com +1 800 591 9710 This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. By using our website, you accept our conditions of use of cookies to track data and create content (including advertising) based on your interest. Accept We are proud of Ukraine’s resilience! Dear Customer, Life Chemicals has fully resumed its production and services at its Kyiv site, supporting its customers’ HTS and building blocks programs and contributing to the restoration of the country’s economy! Always new and best chemistry – yours to explore! You can place orders and inquiries for the whole stock of our Screening Compounds and Building Blocks . Contact us at orders@lifechemicals.com for more information and quotations. The Life Chemicals Team is confident of the Company’s strong potential to quickly and successfully restart and grow, keeping pace with the highest market demands! STAND WITH UKRAINE: CLICK TO DONATE! For your convenience, we have also prepared a list of our selected products that are readily available for swift delivery worldwide directly from our USA- and Germany-based facilities: Pre-plated Diversity Sets , Pre-plated Focused Libraries , Pre-plated Fragment Screening Sets , Building Blocks (USA & EU Stock) . Please note that Ukranian courier services are not completely operational due to Russia’s invasion of Ukraine, and the delivery time for the main stock may take longer than usual. Thank you for your understanding and support! Yours sincerely, Life Chemicals team Close