Bienta Contract Research Services: HTS, ADME, toxicity, lead opt

[http://bienta.net/] Navigation Menu Home About Us Our Mission Scientific Leadership Strategic Partners Certificates Publications Resources Molecular Screening (HTS) Laboratory Bioanalytical Laboratory Molecular Modeling Group Services Molecular Screening (HTS) ADMET and Pharmacokinetics Animal Studies In silico modeling and chemoinformatics News Careers Photo Video Contact us Integrated Projects Medicinal Chemistry, Molecular Modeling, High-Throughput Screening, ADME-Tox. Weeks from in silico data set to hits and leads. Reliability All laboratories at Bienta operate according to the standard international quality control practices. Bienta holds a permit from Ukrainian regulatory agencies to provide analytical support for clinical trial PK/bioequivalence studies in humans. Qualified staff: All of our personnel hold M.S. and Ph.D. degrees in Chemistry/Biology and many staff members have years of working experience in various research centers of the US and Europe. Striving for excellence: Outsource your research to the largest drug discovery CRO in Ukraine. We build our competitiveness on the integration with the established leader in screening compound libraries and custom chemistry and recruitment of the best local scientists in an emerging Eastern European economy. Integrated Projects A synergy of Enamine Chemistry and Bienta Biology: Medicinal Chemistry, Molecular Modeling, High-Throughput Screening, ADME-Tox. Weeks from in silico data set to hits and leads. Reliability All laboratories at Bienta operate according to the standard international quality control practices. Bienta holds a permit from Ukrainian regulatory agencies to provide analytical support for clinical trial PK/bioequivalence studies in humans. Qualified staff: All of our personnel hold M.S. and Ph.D. degrees in Chemistry/Biology and many staff members have years of working experience in various research centers of the US and Europe. Striving for excellence: Outsource your research to the largest drug discovery CRO in Ukraine. We build our competitiveness on the integration with the established leader in screening compound libraries and custom chemistry and recruitment of the best local scientists in an emerging Eastern European economy. About Bienta Bienta is a trademark for preclinical biology services of Enamine , the world’s largest supplier of drug-like molecules for drug discovery research. Bienta is operating as a Contract Research Organisation (CRO) providing biomolecular screening (HTS) services as well as comprehensive bioanalytical support of drug discovery projects, including in vitro ADMET (absorption, distribution, metabolism, excretion, toxicity) testing as well as pharmacokinetics (PK) and toxicity studies in animals. Time- and Cost-Effective Screening Rapid direct access to the vast Enamine’s off-the shelf compound collection ( Screening Collection ) and Enamine’s explored virtual chemical space for drug-like structures ( REAL Database™ ), in combination with the powerful in-house chemoinformatics and molecular modeling, enables an exceptionally efficient iterative screening, making it possible to step forward from in silico screening sets to the lead generation stage in weeks. High Throughput Screening & ADME-Tox Services HTS Lab at Bienta is a well-equipped screening facility with a broad range of robotic liquid handling and signal readout technology capabilities as well as the capacity to run both biochemical and cell-based assays in 384-well plate format. Bioanalytical Lab is established to provide all common in vitro ADMET tests as well as analytical support of pharmacokinetics and animal tox services. Discover your molecules with us Gallery Read More News & Events Oct 11, 2017 IPAB Contest Results Publication in Nature Sci.Rep. Just out of print: an article with the results of IPAB* contest in Japan was published in Nature Scientific Reports. A compound library was originally provided by Enamine Ltd. and contained 2,382,017 of the stock compounds. In this work, BIENTA performed high-throughput screening of the compounds, based on inhibition activity and results. The screening was conducted in three steps consisting of... Sep 29, 2017 ELRIG Drug Discovery 2017 Please attend Enamine/Bienta G5 booth at the ELRIG Drug Discovery 2017 Meeting! At the photo: Iaroslava Kos, Ph.D., Bienta Business Development Manager, is presenting our poster “Differential Scanning Fluorimetry Provides High Throughput Data on Novel SIRT1 Inhibitors”. The poster is available here. Enamine/Bienta Booth at the ELRIG Drug Discovery 2017 Meeting: Tetiana Matvijuk, Michael Bossert and Iaroslava... Sep 20, 2017 Bienta at MIPTEC 2017 in Basel Researchers from Bienta/Enamine presented a poster during MIPTEC exhibition’2017 in Basel, Switzerland: “Reduced cardiotoxicity of spiro-tetrahydropyran bupivacaine analogues”. The goal of this study was to create active structural analogs of bupivacaine with reduced general and cardiotoxicity due to in silico modifications designed to affect their interaction with Nav1.5 channel, which is believed to be the main target of bupivacaine toxicity. Poster Basel... Read More 2M2.org