Antiviral, anticancer drugs and vaccines for introductions

Products of Mechnicov Institute of Microbiology and Immunology : The institute searches for financing for studies and introductions finished of such scientific development: 1. Oral polyvalent protein-polysaccharide vaccine with acylated antigens for prevention of Diphtheria and Pertussis . Oral administration of this vaccine in rabbit induced protect titer of specific antibody 1:5000. For oral monocomponental vaccins such result is received for the first time in the world. Similar results are received and for oral application of vaccines on the basis of chemically modified viral antigenes. 2. Antiherpetic unguent Gammavir. The medical effect of the ointment application is shown in 60 minutes after purposes, the anesthetizing effect comes after 30 minutes after the drawing, full healing herpetic defeats is observed for 24 hours. Ointment developed with application of Drug-design technologies also does not contain new xenobiotics. The medical effect of ointment is based on ability of some drugs known and resolved to medical application on other purpose to block replication herpesviruses. Ointment also has shown strong local immunomodulation effect. Ointment has shown efficiency at 92 % of treated animal, and its application led to long remissions more than 12 months. 3. A self-adapting anticancer antibiotic Antican. This preparation contain succinylated alpha - interferon and succinylated interleukin-2 in liposomal form. The sorbent (in liposomal bilayer) taking antibody from a patient's serum blood and insert its in a liposomal membrane. As is known, in cancer patients all antibodies sick more a half it is anticancer antibodies. Introduction of blood plasma of the concrete patient in a preparation leads to effect of liposomes adaptation and occurrence in them of vector (targrting) properties to a concrete tumour. Accumulation in a tumour in greater concentration of interferon and interleukin leads to activation of specific anticancer immunity and in 53 % of cases to the tumours regress. Acylation of interferon and interleukin has led to their increase affinity to its receptors more than in 100 times. 4. Technology of increase of sensitivity, specificity and stability of antibodies . The way is based on increase affinity antibodies to its target after partial acylation their structures. Specificity thus increases up to 10 times, sensitivity 70 times, stability 3 times. The given technology can be used by development of medical antibodies (anticancer and antiviral) as allows to reduce concentration of active antibodies in the medicinal form in 70 times. 5. Technology specific genes inactivation. The technology is based on ability of acylated polynucleotid (for acylation use chloranhydride of oxalic acid) is specific hybridized only with the nonacylated predecessor. The given technology opens wide prospects and a new direction in gene therapy - specific chemical genes inactivation. Acylated DNA (RNA) chain and structures formed as a result of hybridization are steady against nucleases action. High anti-viral activity of acylated primers from herpetic PCR-TEST-SYSTEM is shown in vitro. For Contact: Arthur Martynov, Pharm.D., Ph.D.,Sc.D., academic secretary of the Institute E-mail: imiamn@mail.ru [mailto:imiamn@mail.ru] , Phone: +380577313151, Fax: +380577313469