Med. Ecol. Problems Vol . 9, ¹5-6, 2005
Sargosh Î.D.
ANALYSIS OF DOSE LOADING ON WORKERS OF "POLTAVANAFTOGAZ" ENTERPRICE  Med. Ecol. Problems.-2005.-Vol.9, N5-6.- P.43-47. In work there are the analyzed results of individual dosimetria control of conducted on the separate objects of industry on the booty of oil and gas, on which the exposed technologically-increased radio-active sources of natural origin. Conducted radiation-hygienical estimation of the dose loading on the workers of oil and gas complex of the Poltava region, on the example of the OGBO "Poltavanaftogaz" enterprise.

Burya L.V., Katrushov A.V.
HYGIENICAL ESTIMATION OF LIGHT LEVEL IN STOMATOLOGY CABINETS AT THE USE OF COMPOSITION MATERIALS  Med. Ecol. Problems.- 2005.- Vol.9, N5-6.- P.39-42. The results of researches of luminosity of cabinets of therapeutic stomatology during work with composition materials are represented. It is set that work with fotopolymeryzator creates the additional loading on the organ of sight. Recommendations of work with gelyokompozyte material in the first half of working day are grounded.

Novikov V.N.
OCCLUSIAL CORRECTION DURING INFLAMMATORY DISEASERS OF TEMPORO-MANDIBULAR JOINT  Med. Ecol. Problems.-2005.-Vol.9,N5-6.-P.36-39. In this article the plan of prosthetic treatment and the principle of the choosing of occlusial bite-plates during inflammatory non-specific diseasers of temporo-mandibular joint is proposed. The state of patients is estimated by magnetic-resonance tomography and electric miography in the direct connection with functional occlusion. Splint construction choice is recommended to pass after complex research of TM with account of joint, muscles and occlusial factors.

Avetikov D.S.
TREATMENT AND PROPHYLAXIS OF COMPLICATIONS CPLD WITH VIOLATION OF CIRCULATION OF BLOOD IN ÀÍÃÈÎÑÎÌÍÛÕ ÀÓÒÎÒÐÀÍÑÏËÀÍÒÀÒÀÕ DURING LEADTHROUGH OF PLASTIC RECONSTRACTION OPERATIONS ON HEAD AND NECK Med. Ecol. Problems.-2005.-Vol.9,N5-6.-P.34-35. One of the most frequent complications of plastic and reconstruction operations and the principal reason of their unsatisfactory ends is violations of circulation of blood in the displanted fabrics. They arise up at transplantation of complexes of fabrics with axial character of especially often at their autotransplantation with imposition of microvascular inosculations. In last case frequency of complications such achieves 18-22%. Most often (75% cases) violations of circulation of blood have the same mechanisms of development and is begun with the mechanical compression of veins providing the outflow from the displanted fabrics. Treatment of such violations requires the removals of reasons, them causing and the use of methods of prophylaxis of metabolic violations developing in fabrics at their insufficient feed.

Chornobay A., Kaydashev I.
APOPTOSIS OF PERIPHERAL BLOOD LYMPHOCYTES IN PATIENTS WITH MALIGNANCIES OF RECTI, UTERI CERVICS AND OVARII AND ITS DEPENDENCE ON THE TREATMENT Med. Ecol. Problems.-2005.-Vol.9,N5-6.-P.30-33. Apoptosis of peripheral blood lymphocytes was studied by flow cytometry with annexin V-propidium iodide test. Patients with malignancies had the apoptosis increased wich was in 6-12 times higher than in healthy individuals. The treatment of patients decreased the level of lymphocyte apoptosis, especially, by the using of the endolymphatic chemotherapy.

Mosiychuk L.N.
VARIANTS OF INTERACTION BETWEEN AGGRESSIVE AND DEFENSIVE FACTORS IN PATIENTS WITH ACID-RELATED DISEASES Med. Ecol. Problems.-2005.-Vol.9,N5-6.-P.25-30 In the article there were revealed the function of a stomach in patients with the duodenal ulcer (DU) and gastroesophageal reflux diseases (GERD) as well as in case of their combination. There were determined the most characteral variants of interaction between aggressive and defensive factors of gastric mucosa. In most of patients with DU there was the decrease of defensive factors and the increase of aggressive factors. In patients with GERD more characteristic was compensatory increase of content of the gastromucoprotein and the fucosa in case of action of aggressive factors. The received data are necessary for taking into consideration for therapeutic strategy of acid-related diseases.

Matyokha T.
INFLAMMATORY DISEASES PREVENTION FOR PATIENTS, USING INTRA UTERINE DEVICES CONTRACEPTION TECHNIQUE  Med. Ecol. Problems.-2005.-Vol.9, N5-6.-P.21-24 The sanitation of genital tracts in infected women was performed before the introduction of intrauterine contraceptive. The morphological structure of the endometrium was renewed and brought into line with healthy women. The local cell immunity indexes became nearer to the same indexes as in uninfected women according to their quantity and localization. When using the intrauterine contraceptive, the frequency of complications was considerably reduced.

Drannik G.N., Kologrimova V.V., Poroshina T.V., Driyanskaya V.E., Negrey L.N., Fesenkova V.Y.,Savchenko V.S., Korol L.N.
THE CHARACTERISTIC LEVEL OF PRO- AND ANTI-APOPTOTIC MARKERS IN PATIENTS WITH UROGENITAL CHLAMYDIOSIS AND THE INFLUENCE OF IMMUNOMODULATORS ON IT  Med. Ecol. Problems.-2005.-Vol.9, N5-6.- P.19-21. The aim of this work is to investigate the level of mononuclear cells of patients with urogenital chlamydiosis, expressing Fas-receptor (CD95+) (pro-apoptotic factor) and also Bcl-2 (anti-apoptotic factor) and influence of immunomodulators on it. The investigation demonstrated the objective elevation in marking level of blood lymphocyte activation in patients with chronic inflammatory diseases of urinary system; at the same time, the number of CD95+-cells in patients with chlamydiosis objectively exceeded these reading both in healthies and in patients without Chlamydia trachomatis. There were determined the effects of Manaxx and Erbisol in vitro on the level of CD95+ and bcl-2 in patients with chronic urogenital chlamydiosis.

Tyupka T.I.
THE INFLUENCE OF ENAP ON THE PHOSPHOLIPID COMPASITION OF CARDIOMIOCYTES MEMBRANES BY HEMODINAMIC PULMONARY OEDEMAE  Med. Ecol. Problems.-2005.-Vol.9,N5-6.-P.16-18. In experiments, the changls of the phospholipid compasition of cardiomiocytes membranes in rats by haemodinamic pulmonary oedemae were studied. Rats were treated with or without angiotensine-converting enzime inhibitor – enap. During experimental pulmonary oedemae there were the increase of the whole phospholipids content in miocardium due to an activation of simpatic system. Enap influenced on the pulmonary oedema positively, increased miocardium resistance to ischemic injury (the increase of phosphatidylinosit, phosphatidylcholine and the decrease of phosphatidyletanolamine).

Kononenko N.N.
HEMOCOAGULATION AND FIBRINOLYSIS BY THE EXPERIMENTAL ULCER OF A STOMACH  Med. Ecol. Problems.-2005.-Vol.9, N5-6.-P.13-16. It was shown, that at an experimental ulcer of a stomach on Î kabe there is a moderate hypercoagulation, caused by drop anticoagulation of properties of a blood, is especial of activity of antithromboplastin and antithrombin ²²² . The fibrinolytic activity of a mucosa of a stomach and abjection from it of plasminogen activators and plasmin in a blood stream strengthens. A plasmin, rendering proteolytic action on fibrinogen and the fibrin, results in sharp kerf of hypocoagulation that can promote a helcomenia. An agent of pathogenetic prophylaxis of this complication can be aboriginal application of inhibitors of fibrinolysis.

Peshkova O.V.
THE MODERN APPROACHES TO EARLY DIAGNOSIS OF THE OVERTRAINING SYNDROME AT THE SPORTSMEN Med. Ecol. Problems.-2005.-Vol.9,N5-6.-P.8-12. The existing approaches to diagnostics of the overtraining syndrome at the sportsmen are characterised. Is offered and the efficacy of new methods of early diagnosis of the overtraining syndrome at the sportsmen with use of two bunches of the motorial tasks with the count of an orientation of sports activity is confirmed.

Toryanik E,L., Bereznyakova M,Y., Shevtsov I.I., Bolotov V.V., Kolesnik S.V.
Pharmacological effect of Amid 2-oxoindolin-3-glioxil of an acid  Med. Ecol. Problems.-2005.-Vol.9, N5-6.-P.6-7 The influence of Amide 2-oxoindolin-3-glioxil of an acid on fabric respiration is investigated. The concentration of a pyruvate and sodium lactate in a blood of rats is spotted at hemic hypoxia in different terms of experiment (1, 3, 5, 7 and 10 days). Wt suggest, that Amide 2-oxoindolin-3-glioxil of an acid boosts fabric respiration, activating processes of a glycolysis.

Gnatyuk V.V., Bereznyakova A.I.
EFFICACY OF SUPPOSITORIUM "PANTHESIN" ON STREAMING OF AN EXPERIMENTAL PROCTITIS CAUSED BY A RECTAL ADMINISTRATION OF PHENOLUM Med. Ecol. Problems.-2005.- Vol.9, N5-6.-P.3-5. The results of efficacy of the suppositorium "Panthesin" are submitted at an experimental proctitis caused by the phenolum. It is shown, that suppositoria do not influence the clinical parameters of a blood, mass of a body and rectal temperature in rats, reduce the area of a necrosis of rectal mucosa, quantity of dotted hemorrhages and awakely neogenesis of a mucosa.

Medical and Ecological Problems Vol.9, ¹3-4, 2005
Treumova S.I.
NO METABOLITE LEVEL IN PATIENTS WITH CHRONIC PULMONARY HEART SYNDROME Med. Ecol. Problems.-2005.-Vol.9,N3-4.P.38-39. The paper represents the study of NO metebolite level in patients with chronic pulmonary heart syndrome. It has been found out that the progress of the disease was accompanied with no exhausing. These alterations were the most expressed during the period of decompensation due to hypoxia and free radicals growth.

Ulanovskaya-Tsiba N.A.
STRUCTURAL-FUNCTIONAL ANALYSIS OF STRUCTURE OF GALL-BLADDER WALL IN AGE ELDER 55 YEARS Med. Ecol. Problems.-2005.-Vol.9,N3-4.P.32-35. By the method of microscopic research (hematoksilin-eozin, Van-Gizon's and Hart's staining) the structural-functional changes of structure of gall-bladder wall of man were set in age elder 55 years. It was studied structure of mishechnogo and mucous layer, on a structure and state. These changes in a mucous membrane are more expressed, more precisely in its folds.

Tsepkolenko V.A.
CLINICAL AND EPIDEMIOLOGICAL CHARACTERISTICS OF GYNECOLOGIC DISEASES IN WOMEN WITH COSMETIC DETERIORATION OF FACE SKIN OF DIFFERENT LEVEL OF PRONOUNCIATION  Med. Ecol. Problems.-2005.-Vol.9,N3-4.P.28-31. In women with excessive wrinkles of face skin the incresead index of gynecological deseases, especially of inflammatory origin was registered in comparison with the control group of age- mathced practically healthy women. In referent group the ovarian cycle disturbing was also significantly pronounced, and higher level of algomenorrhea along with menometrorraghia, pre- and postmensis bleeding along with reduced oligo- and dysmenorrhea and mixed form of disturbances were registered when compared with proper age- mathced controls. Aging dynamics of opsomenorrhea was opposite to corresponded analogous index in control groups with natural involution of reproductive system. That might be in favor of different mechanisms of skin deterioration in normal aging and in processes which are resulted in aesthetic skin problems.

Yarynich-Buchinskaya N.P., Skripnikov P.N., Kaidashev I.P.
EXPERIMENTAL THERAPY OF SPONTANEAUS PERIODONTITIS BY EMBRIONIC TISSUES` PREPARATIONS Med. Ecol. Problems.-2005.-Vol.9,N3-4.P.23-27. The processes in rat periodont tissues with the injection of suspensions of embrionic nervous tissues and bone particles were studied. Affer 30 days of implantation we observed the low eficiency of this therapy and exacerbation of chronic inflammation even. The therapy by combined preparation of bone and cartilape particles was more preferable.

Chikor V.P.
BIOELECTRIC PROCESSES IN MIMIC MUSCLES OF A UPPER LIP DURING THE ADAPTATION TO COMPLETE REMOVABLE DENTURES Med. Ecol. Problems.-2005.-Vol.9,N3-4.P.19-21. It was investigated the quantitative parameters of electromyograms of a upper lip muscles in 11 edentulous patients before treatment and during the adaptation to complete removable dentures. Also it was 7 observed persons without the defects of teeth lines. It is shown, that activity coefficient and the amplitude of mimic muscles biopotentials are diminished. The restoration of these parameters is characterized by its own dynamics. It is developed during 30 days after first dentures using.

Chizhevsky I.V., Gubanova O.I.
STATE OF HUMORAL IMMUNITY OF CHILDREN WITH MULTIPLE CARIES OF TEETH IN DONBASS Med. Ecol. Problems.-2005.-Vol. 9, N3-4. P.16-18. The indices of general humoral immunity have been studied in children 14,5 – 15,5 years old, living in conditions of industrial pollution. Quantity and quality specifications of B-cells and immunoglobulin A, M , G were determined. Inhibition of all units of general immunity in children with multiple caries was revealed. Misbalance between quantity of B – cells and their functional activity was noticed. It was determined in both groups.

Bereznyakova M.Y., Toryanik E.L., Shevtsov I.I., Bolotov V.V., Kolesnik S.V.
ANTIOXYDANT ACTIVITY OF NEW DERIVANT 2-OXOINDOLIN-3-GLIOXIL OF AN ACID Med. Ecol. Problems.-2005.-Vol.9,N3-4.P.14-15. The influence of a new derivant 2-oxoindolin-3-glioxil on activity of a peroxide oxidizing of lipids is investigated at stress-pain damage of a cardiac muscle. Is shown, that an antioxydant effect of a new derivant 2-oxoindolin-3-glioxil is implemented as a result of downstroke of the content of primary molecular yields of a peroxide oxidizing of lipids in tissues and blood.

Kostrikova J.A., Khilko J.K., Lutsenko B.O.
THE DALARGINE INFLUENCE ON CICATRIZATION OF SHARP ACETATE GASTRIC ULCERS AT EXPERIMENTAL ANIMALS  Med. Ecol. Problems.-2005.-Vol.9,N3-4.P.1 1 -13 Experimental work is devoted to the study of influencing of dalargine on the reparation regeneration of sharp acetate ulcers at rats in comparison with a control group. It is shown that correction of dalargine do more quickly reparation processes. At the same time this preparation does not hinder to formation of surplus joints, that also characteristically for a control group and shows up expressly expressed metaplasia gullet epithelium on the edges of ulcerous defect.

Voskresenskaya L.K., Kaydashev I.P. Kornienko V.V. Maksakova E.V. Sobko K. G. Riadnova V. V.
INFLUENCE OF THE PEPTIDE PREPARATION “VERMILAT” ON REPARATION PROCESSES OF THE CORNEA BY TRAUMATIC INJURIE  Medical and Ecological Problems.-2005.-Vol.9,N3-4.P.7-11. It was fixed, the reaction of the eyes structures on different doses of the polypeptide preparation by subconjunctival injections. It was shown, that in the rabbits with traumatic injuiry of cornea a polypeptide preparation is influencing on the reparation processes at the expense stimulation of the endogenic fibronectin by high level hlicosaminoglycanes.

Vesnina L.E., Kaidashev I.P.
KIDNEYS PEPTIDE COMPLEX INVOLVEMENT IN INTRACELLULAR PROTHEIN THYROSINE PHOSPHORYLATION PROCESSES  Med. Ecol. Problems.- 2005.- Vol.9, N3-4. P.3-7. The intracellular prothein thyrosine phosphorylation processes involvement the possibility in kidney peptide complex (KPC) membrane-like action implementation on lymphocytes is researched. The phosphothyrosine molecules intensity expression significant increasing is defined at 10-minute lymphocytes incubation with KPC, which at PMA preliminary stimulation reaches maximum value. We consider, that KPC can attract lymphocytes membrane prothein thyrosine phosphorylation processes for its membrane-mediated influence implementation. The phosphothyrosine expression intensity intensifying after 10-minute incubation confirms KPC influence possibility on signal transduction initial stages, in particular, on enzymes activity with thyrosinkinase activity. More remote on time (120 minutes), the KPC influences on phosphorylation processes, quite probably, can testify to KPC influence on signal transduction stages, that are realized at enzymes cascades stages level, which interact with nuclear transcription factors.

Medical and Ecological Problems Vol. 9, ¹1-2, 2005
Moskovko S.P.
RECENT CLINICAL STRUCTURE OF PARKINSON'S SYNDROM: RESULTS OF COHORT EPIDEMIOLODGIC STUDY Med. Ecol. Problems.-2005.-Vol.9,N1-2.P.30-32. Within the framework of population epidemiological research the cohort of patients with parkinsonian syndrome is allocated. With application of consecutive clinical diagnostic algorithm the modern nosological structure have established. Idiopathic Parkinson's disease makes 68 - 75 % of cases. The multiple system atrophy is found out in 4,3 % of patients, progressive supranuclear palsy at 2,96 %, corticobasal degeneration at 1,34 % and a vascular parkinsonism at 3,5 % of patients. 9,68 % of observations have made cases of "atypical parkinsonism" in which at the moment of inspection is not present enough data for exact nosological qualification.

Rudenko Y.S.
HYGIENIC SIGNIFICANCE AND INFORMATION VALUE OF MICROORGANISMS IN THE ASSESSMENT OF THE DENATURATION OF SEA ENVIRONMENT  Med. Ecol. Problems.-2005.-Vol.9,N1-2.P.27-30. It was analyzed the possibility to use representatives of autochtonic and allochtonic microflore as the indicators of the denaturation of sea environment by detergents (sulfanole, bovine serum). It's shown the significance of intestinal microflore for assessment of the rate and character of the contamination of sea environment.

Lutzenko N.N., Skrypnikov N.S., Pronina E.N.
HYSTOTHOPOGRAPHY LYMPHATIC VESSELS OF A MUCOUS MEMBRANE LABYRINTH IN OS ETHMOIDALE IN THE PERSONS WITH ELDERLY AND SENILE AGE Med. Ecol. Problems.-2005.-Vol.9,N1-2.P.23-26. It was estimated the peculiarities of hystothopography of lymphatic microcyrculation network of mucose of the os ethmoidale labyrinth in elderly and senile persons. The work is carried of the os ethmoidale labyrinth. In elderly and senile persons lymphatic vessels were changed significantly. The reduction of lymphatic vessels appears. Since the age unclosed loops are defined in lymphatic capillaries network. Capillary sidebars become uneven. Clear space narrowly at part of them is devastated. Orientation on loads of lymphatic network is net. The are many vessels dilatations of the bud – similar form with wide basis, spherical, mushroom, hook- similar form.

Vesnina L.E.
PECULIARITIES OF THYMALINE INFLUENCE ON LYMPHOCYTE ANTIGEN DETERMINANTS UNDER THE ENDOGENOUSE IMMUNOMODULATORS ACTION CONDITIONS  Med. Ecol. Problems.-2005.-Vol.9,N1-2.P.18-22. The peculiarities of thymaline influence on lymphocytes antigen determinants at endogenous immunomodulators IL-2 and Hydrocortizone action for its comparison with kidney peptide complex (KPC) action were investigated. The obtained datas testify, that at IL-2 action under thymaline influence a direction of changes in the side of CD3 expression increasing, CD8, CD72 – decreasing, is remaind excepted HLA-DR. The decreasing of generated caps and patches, the increasing of clusters – is the common tendency of receptors redistribution character changes. It was not the characteristic for KPC action. At Hydrocortizone action thymaline, as well as KPC, CD3 and CD8 expression increased, HLA-DR – decreased, but CD4 expression level increased. The receptors regrouping under thymaline influence occurred directionally to KPC action. The results received give the basis to consider that peptide substances of a different origin (central – thymaline, peripheral – KPC), possess similar immunomodulation action, as for developmental mechanisms, which is the manifestation of common nonspecific influence of regulative peptides on immunity system.

Tkachenko P.I., Zadoya N.I.
AKUPRESSURA – METHOD OF THE PREMEDICATION IS AT SURGICAL STOMATOLOGY INTERFERENCE IN CHILDREN  Med. Ecol. Problems.-2005.-Vol. 9, N1-2. P.14-17. With the purpose of providing of decline of level of sensory perception and removal of negative reactions of the vegetative nervous system the large value has application of new methods of premedikation. As such method in a clinic all wider different methods of refleksoanalgezii are used, one of which is a point massage. In this article include research results at the use as sedative preparation of children to operative stomatology operative intervention the complex of akupressyri.

Skrypnikov N . S ., Mitchenok V . I ., Kolesnik I.A., Pankevych A.I., Gorbachenko O.B. PERSPECTIVES AND PROBLEMS OF APPLICATION OF CRYOPRESERVED STEM CELLS IN TREATMENT OF VEGETATIC GANGLIONITISES OF THE HEAD  Med. Ecol. Problems.-2005.- Vol.9, N1-2. P.11-13. In the work there were analyzed the advantages of application of embryonic stem cells and their properties. There was proposed the use of transplantation of cryopreserved stem cells for the treatment of vegetative ganglionitises of the head. To achieve maximal effect of transplantation there were worked out and grounded the methods of the most precise of bringing up of a transplantant to the ganglion depending on its topographo anatomical position. There was conducted the treatment of 14 patients suffered from vegetative ganglionitises of the head by transplantation of embryonic nervous tissue. The observation for the patients for the period of 12 months allowed to come to the conclusion that the embryonic nervous tissue transplantation may be proposed into clinical practice as an effective method of vegetative ganglionitises of the head treatment.

L.L. Vorontsova
DEPARTMENT OF CLINICAL LABORATORY DIAGNOSTICS OF THE ZAPOROZHIAN MEDICAL ACADEMY FOR ADVANCED POSTGRADUATE EDUCATION  Med. Ecol. Problems.-2005.-Vol.9,N1-2.-P.7-10. Indexes of oxidative stress and endogenous intoxication at patients with the larynx cancer after courses of the combined therapy Indexes, characterising oxidative stress, level of endogenous intoxication, in particular LPO-AOS, oxidative modification and defragmentation of blood serum proteins, and also products of metabolism of low and middle molecular weight had been studied at patients with the larynx cancer after surgical treatment and courses of radiotherapy. Researches were conducted taking into account a temporal dynamics through 1, 3 and 6 months from the moment of conducting of operation. It is shown, that after the conducted therapy the expressed metabolic violations saved during great while are marked.

Avetikov D.S.
SURGICAL METHODS OF DIRECTED OF REINNERVATION| FABRICS AT TREATMENT OF PATIENTS WITH DEFECTS AND DEFORMATIONS OF HEAD AND NECK  Med. Ecol. Problems.- 2005.- Vol.9, N1-2.- P.3-4. Renewal of normal sensitiveness of the displanted fabrics is|appears| the ideal of plastic surgery, which in most cases is unattainable in connection with objective conformities to the law of processes of the regeneration of nervous explorers. It was a research purpose to define the mechanisms of reinnervation| fabrics and to optimize the methods of surgical directed reinnervation|. Geterotopic.| reinnervation| fabrics is carried out by sewing together of sensible nerve of recicient| bed with the motive nerve of the displanted muscle. Implantantic reinnervation| fabrics is carried out by the apartment of the end of sensible nerve of perceiving bed (or the transplant connected with him) in the hypodermic cellulose of skinning-fatty or| shred. The attempts of combination of geterotopic| and implantantic.| methods of sensible reinnervation| fabrics were conducted in our clinic, that gives a good result in a postoperation| period